Actinomyces abscess mimicking mandibular bone cyst PDF
A radiolucent, well demarcated right mandibular bone lesion with a clinical presumptive diagnosis of solitary bone cyst was surgically excised in a 60year old woman. The histopathologic examination revealed Actinomyces colonies surrounded by chronic gr
Acute otitis media caused by Streptococcus pneumoniae serotype 19A ST320 clone: epidemiological and clinical characteristics PDF
Background: Streptococcus pneumoniae serotype 19A ST320, a highly multiresistant and virulent clone, has emerged as a common pathogen causing acute otitis media (AOM) in children.
Diagnosis, Prevention, and Treatment of Catheter- Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America PDF
Catheter-associated (CA) bacteriuria is the most common health care–associated infection worldwide and is a result of the widespread use of urinary catheterization, much of which is inappropriate, in hospitals and longterm care facilities (LTCFs)
Direct Immunofluorescence Study in Discoid Lupus Erythematosus PDF
Diagnosis of a classical case of Discoid lupus erythematosus (DLE) is generally clinical. However, histopathological study of skin biopsy is helpful to confirm the diagnosis in early DLE lesions and in DLE variants. There is however paucity of large st
Fluoroquinolone-nonsusceptible Streptococcus pneumoniae isolates from a medical center in the pneumococcal conjugate vaccine era PDF
Background/Purpose: Streptococcus pneumoniae is one of the most common pathogens to cause mucosal and invasive infection in humans. Resistance to fluoroquinolones (FQ) is associated with clinical failure when treating pneumococcal diseases and increase
High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the “SET” feature of high-grade serous carcinoma to the “STEM” feature PDF
High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphologica
Histopathological Spectrum of Gall Bladder Lesions in A Tertiary Care Hospital in The Malwa Belt: A Hospital Based Study PDF
Gallbladder stones are commonest disorder among gall bladder lesions and are usually asymptomatic. Its frequency in cholecystectomy specimens is not clear. The aim of this study was to report the morphological variants and frequency of different lesion
Histopathological Spectrum of Nephrectomy Specimens PDF
Kidneys are the vital organs of the body which are having multiple functions. The benign or malignant diseases of the kidney result in total organ removal. Renal tumorscomprise a wide spectrum of neoplastic lesions with patterns that are distinct for c
Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon PDF
Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The spread of multidrug-resistant A. baumannii is a major public health problem. The aim of this study was to investigate the molecular epidemiology and the gen
Non – Functioning Adrenocortical Carcinoma – Report of a Case and Review of Literature PDF
Adrenocortical carcinomas (ACC) are rare aggressive tumors with poor prognosis. Their annual incidence is 0.6 – 1.67 cases per million population per year.
Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases PDF
Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations. A pathological class
Pathophysiology of Sickle Cell Disease PDF
Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. In SCD, a single amino ac
Prevalence of Toxoplasma gondii Antibodies and DNA in Iranian HIV Patients PDF
Toxoplasma gondii infection has public health importance and can lead to serious diseases in immunosuppressed patients, such as HIV cases. Appropriate control of T. gondii infection in HIV patients requires information about the prevalence of T. gondii
Quinolone resistance phenotype and genetic characterization of Salmonella enterica serovar Pullorum isolates in China, during 2011 to 2016 PDF
Pullorum disease, caused by Salmonella enterica serovar Pullorum (S. Pullorum), is one of the most important bacterial infections in the poultry industry in developing countries, including China. To examine the prevalence and characteristics of S. Pull
RAS genes in colorectal carcinoma: pathogenesis, testing guidelines and treatment implications PDF
The RAS family is among the most commonly mutated genes in all human malignancies including colon cancer. In normal cells, RAS proteins act as a link in the intracellular signal transduction initiated by binding of growth factors to cell membrane recep
Screening for mutations in two exons of FANCG gene in Pakistani population PDF
Fanconi anemia is a rare autosomal recessive disorder of genetic instability. It is both molecularly and clinically, a heterogeneous disorder. Its incidence is 1 in 129,000 births and relatively high in some ethnic groups. Sixteen genes have been ident
Submucosal Calcifying Fibrous Tumor of Stomach: A Rare Case Report PDF
Intrinsic visceral gastric calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor often noted as an incidental finding. We herein present a case of a 42 year old male who on evaluation for pain abdomen was found to have calculous cholecystit
T cell clonality assessment: past, present and future PDF
T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including T cell on
The effect of antimicrobial drug use on the composition of the genitourinary microbiota in an elderly population PDF
The urinary tract is inhabited by a diversity of microorganisms, known as the genitourinary microbiota. Here, we investigated the association between the use of antimicrobial drugs and the composition of the genitourinary microbiota.
The effect of immunization with pneumococcal conjugated vaccines on Streptococcus pneumoniae resistance patterns in acute otitis media PDF
Following the introduction of 7- and 13-pneumococcal conjugate vaccines (PCVs) in Israel, we demonstrated that within Streptococcus pneumoniae (Sp) positive middle ear cultures, obtained from young children with severe acute otitis media (AOM) episodes
USA300 Staphylococcus aureus persists on multiple body sites following an infection PDF
Background: USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a community- and hospital-acquired pathogen that frequently causes infections but also can survive on the human body asymptomatically as a part of the normal microbiota. We devise